Stress is the most important risk factor associated with seizure incidence, frequency and severity. Although numerous animal studies suggest early programming with stress influences seizure disorders and their prognosis, developmental human studies of this link are lacking. Hence, this study aimed at investigating stress biomarkers in children with prior simple or complex febrile seizures, compared to matched controls. The main objectives are 1) studying stress biomarkers in children with past febrile seizures, compared to their peers and 2) study the influence of stress biomarkers on the cognitive prognosis of children with febrile seizures. Results drawn from this study may further our understanding of the link between early-life stress and seizures.
